Company Profile

Nalpropion Pharmaceuticals, Inc. was formed on April 17, 2018 as a joint venture among Pernix Therapeutics Holdings, Inc., Highbridge Capital Management, LLC and Whitebox Advisors LLC.  Nalpropion was established for the purposes of purchasing substantially all commercial assets of Orexigen.  Nalpropion is a biopharmaceutical company focused on the treatment of weight loss. CONTRAVE® (naltrexone HCl and bupropion HCl extended release), was approved in the United States in September 2014 and has become the most prescribed branded obesity medication since June 2015. In Europe, the drug has been approved under the brand name Mysimba™ (naltrexone HCl/ bupropion HCl prolonged release). Nalpropion is undertaking a range of commercialization activities, both on their own and with key strategic partners, to bring CONTRAVE / Mysimba to patients around the world.

About Investors

Pernix, Nalpropion’s operating partner, was formed on November 7, 1996 as a corporation under the laws of the State of Maryland and is traded publicly on The NASDAQ Stock Market. Pernix is a specialty pharmaceutical company with multiple commercialized pharmaceutical products.

Nalpropion’s financial partners, Highbridge and Whitebox, are each leading asset management firms.  Highbridge was founded in 1992 and currently has over $5 billion in assets under management.  Whitebox was founded in 1999 and currently has approximately $6 billion in assets under management.  Each of Highbridge, Whitebox and Pernix have committed sufficient capital to fund the purchase price and the net working capital for Nalpropion.

Important Safety Information for CONTRAVE

CONTRAVE can cause serious side effects of suicidal thoughts or actions. One of the ingredients in CONTRAVE is bupropion HCl. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.

Stop taking CONTRAVE and call a healthcare provider right away if you, or your family member, have any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling very agitated or restless; panic attacks; trouble sleeping (insomnia); irritability; acting aggressive, being angry or violent; acting on dangerous impulses; an extreme increase in activity and talking (mania); other unusual changes in behavior or mood.

While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings and maintain communication with your healthcare provider. CONTRAVE has not been studied in and is not approved for use in children under the age of 18.


Do not take CONTRAVE if you:

  • Have uncontrolled high blood pressure
  • Have or have had seizures
  • Use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, and APLENZIN
  • Have or have had an eating disorder called anorexia or bulimia
  • Are dependent on opioid pain medicines or use medicines to help stop taking opioids such as methadone or buprenorphine, or are in opiate withdrawal
  • Drink a lot of alcohol and abruptly stop drinking, as this may increase your chance of having a seizure; or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti-seizure medicines and you stop using them all of a sudden
  • Have taken medicines called monoamine oxidase inhibitors (MAOIs), including linezolid, within the last 14 days
  • Are allergic to naltrexone HCl or bupropion HCl or any of the ingredients in CONTRAVE
  • Are pregnant or planning to become pregnant. Tell your healthcare provider right away if you become pregnant while taking CONTRAVE

Tell your healthcare provider about all of your medical conditions, especially: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of your brain or spine; low blood sugar or low levels of sodium in your blood; liver or kidney problems; high blood pressure; heart problems or stroke; eating disorder. Also tell your doctor if you drink a lot of alcohol and plan to suddenly stop; abuse prescription medicines or street drugs; are over the age of 65; have any other medical conditions; or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them.

Swallow CONTRAVE tablets whole. Do not cut, chew, or crush CONTRAVE tablets. Tell your healthcare provider if you cannot swallow CONTRAVE tablets whole. Do not take CONTRAVE with high-fat meals. It may increase your risk of seizures. Take CONTRAVE exactly as prescribed.

Possible serious side effects of CONTRAVE: 

  • If you have a seizure, stop taking CONTRAVE, tell your healthcare provider right away, and do not take CONTRAVE again
  • If you take opioid medicines, there may be a risk of opioid overdose. You should get emergency medical help right away if you have trouble breathing; become drowsy with slowed breathing; have slow, shallow breathing; or feel faint, dizzy, or confused
  • Sudden opioid withdrawal can be severe and may require hospitalization
  • Stop taking CONTRAVE and get medical help immediately if you have any of the following signs and symptoms of severe allergic reactions: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing
  • Increases in blood pressure or heart rate may occur
  • CONTRAVE can cause liver damage or hepatitis. Stop taking CONTRAVE if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness
  • Manic episodes can occur. CONTRAVE can cause some people who were manic or depressed in the past to become manic or depressed again
  • CONTRAVE can cause visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your doctor to find out if you are at risk and to get treatment to prevent it
  • Increased risk of low blood sugar (hypoglycemia) in people with type 2 diabetes mellitus who also take medicines to treat their diabetes(such as insulin or sulfonylureas). You should check your blood sugar before you start and while taking CONTRAVE

The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea.

Tell your healthcare provider about any side effect that bothers you or does not go away. These are not all the possible side effects of CONTRAVE.


CONTRAVE is a prescription medicine that contains 2 medicines (naltrexone HCl and bupropion HCl) that may help some obese adults*, or overweight adults who also have weight-related medical problems†, lose weight and keep the weight off.

  • CONTRAVE should be used with a reduced calorie diet and increased physical activity
  • It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke
  • It is not known if CONTRAVE is safe and effective when taken with other prescription, over-the-counter, or herbal weight loss products

*Body mass index (BMI) of 30 kg/m2 or greater.
†BMI of 27 kg/m2 or greater with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes. 

Talk to your healthcare provider. Please see accompanying Full Prescribing Information, including Medication Guide, for CONTRAVE.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.